Institutional Biosafety Committee (IBC) 


 The IACUC and IBC are transferring to a new research database system, TOPAZ Elements. Our go-live date is August 8th.  If your intent is to complete a new biosafety protocol, please wait until the transition to the new system in order to avoid the necessity of duplicate entry into the new system.

Please attend ONE of our Town Hall Meetings to receive information on:

  • Downloading Pulse Secure (feel free to download the required extensions now)
  • Logging-in to TOPAZ Elements (web link will be provided)
  • How protocols have been transferred to the new system
  • Helpful changes to the IACUC protocol form
  • Helpful changes to the IBC protocol form
  • Exciting changes that are to come for Comparative Medicine animal ordering and billing Wednesday, July 27th at 2:30pm in the Library Auditorium (LIB299) or Tuesday, August 2nd at 9:00am in the Library Auditorium (LIB299)  

If you are interested, please stay after the meeting for a quick 5-10 minute “tips and tricks” training session on how to use TOPAZ Elements more effectively.  If you cannot attend, PowerPoint presentations from Town Hall Meetings will be posted on the IACUC and IBC websites, and forwarded via email.

Should you have any questions, please contact the respective office ( for IACUC-related inquiries, or for IBC-related inquiries).

The OUHSC Institutional Biosafety Committee (IBC) has the charge of reviewing and approving the biological safety of all OUHSC and OU-Tulsa basic and clinical research activities involving recombinant and synthetic nucleic acid molecule,* gene transfer including transfer to humans, microorganisms, viruses, and biological toxins. 

The OU-Norman IBC has the charge of reviewing and approving all such work at OU-Norman. 

For information concerning campus-specific procedures/policies, please select the appropriate campus in the Policies Header located at the top of the page. The definition of recombinant and synthetic nucleic acid molecule includes: 

  • molecules that a) are constructed by joining nucleic acid molecules and b) that can replicate in a living cell, i.e., recombinant nucleic acids;
  • nucleic acid molecules that are chemically or by other means synthesized or amplified, including those that are chemically or otherwise modified but can base pair with naturally occurring nucleic acid molecules, i.e., synthetic nucleic acids, or
  • molecules that result from the replication of those described in either of the above.*

* Note that the National Institutes of Health (NIH) Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules has identified criteria for synthetic nucleic acids that are exempt from the NIH requirements. Specifically, synthetic nucleic acids molecules are exempt that:

  1. can neither replicate nor generate nucleic acids that can replicate in any living cell (e.g., oligonucleotides or other synthetic nucleic acids that do not contain an origin of replication or contain elements known to interact with either DNA or RNA polymerase), and
  2. are not designed to integrate into DNA, and
  3. do not produce a toxin that is lethal for vertebrates at an LD50 of less than 100 nanograms per kilogram body weight.


Norman Campus